Snip Snip! CRISPR-Cas9 Genomic Editing Characterizes the Prion Protein Knockout Proteome

via Accelerating Science » Amanda Maxwell http://ift.tt/1ltYPbs

Although prion proteins are widely implicated in the pathogenesis of several neurodegenerative diseases, including Alzheimer’s in animals and humans, their normal physiological function is still relatively unknown. However, Mehrabian et al. (2014) recently published a cell-specific deep proteome analysis that gives the first clues into prion protein function. Using CRISPR-Cas9 technology, the researchers created knockout Read the rest of this article

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