Identifying and Quantifying DNA-Protein Interactomes with Quantitative Proteomics

via Amanda Maxwell – Accelerating Science http://ift.tt/1qDhPqb

Trung et al. (2014) describe a proteomics workflow that replaces in silico modeling with quantitative DNA-protein interactome data.1 The approach uses SILAC (stable isotope labeling of amino acids in culture) to identify proteins interacting with M8, a putative cis-regulatory element that may play a significant role in leukemia and lymphoma development. The M8 motif—TMTCGCGANR, where M Read the rest of this article

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