in, around and in spite of my family: December 2016

Wednesday, December 28, 2016

daily snapshot: December 28, 2016 at 11:01AM

Guesses, no spoilers? #drwho
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Monday, December 26, 2016

daily snapshot: December 26, 2016 at 11:37AM

Rosco's why aren't we moving? face. We're not moving cos I can't get round the full walk this morning. The Cold struck yesterday afternoon, a gift from the mister who went down with it Dec 23. It's hammered my chest, my abdomen with the aches and knocked my balance right off. Luckily it has snowed so this morning's falls have been into the softish stuff rather than last night's ice. Rosco is appreciating slower walks in zigzag direction. Merry Christmas
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Differential Protein Quantitation at the Peptide Level

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Differential Protein Quantitation at the Peptide Level

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Friday, December 23, 2016

Obese and Healthy? Proteomic Biomarkers Give Clues

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daily snapshot: December 23, 2016 at 12:10PM

The season's festive cake; Christmas is underway
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Obese and Healthy? Proteomic Biomarkers Give Clues

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Wednesday, December 21, 2016

LC-HRMS Multi-Allergen Detection of Nuts Contamination

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LC-HRMS Multi-Allergen Detection of Nuts Contamination

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Food Authentication with Proteomic Analysis

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Deep Proteome Characterization Highlights Breast Cancer Cell Functionality

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Mesenchymal Stem Cell Exosome Proteome under Ischemic Culture Conditions

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Tuesday, December 20, 2016

daily snapshot: December 20, 2016 at 07:09PM

Settling back into the apres ski routine at Glenburn Soda ... making an attempt on the nine festive sundaes before the end of December
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Monday, December 19, 2016

Deep Proteome Characterization Highlights Breast Cancer Cell Functionality

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Sunday, December 18, 2016

daily snapshot: December 18, 2016 at 09:16PM

Evening walk with the these two
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Friday, December 16, 2016

Mesenchymal Stem Cell Exosome Proteome under Ischemic Culture Conditions

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Thursday, December 15, 2016

Collaborative Transnational Biobanking for Rare Disease Research

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Wednesday, December 14, 2016

Food Authentication with Proteomic Analysis

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Saturday, December 10, 2016

daily snapshot: December 10, 2016 at 08:27PM

Work in progress #acrylicpainting
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Friday, December 09, 2016

Client showcase: Shelly Deforte, biomathematician

As a full-service science communications agency staffed with editors, designers, writers and more, Talk Science to Me takes great pride in supporting all our clients by presenting their science in effective and engaging ways. Although most of our portfolio comprises larger organizations and institutions, we also work with individual authors and researchers to manage their writing and publishing needs.

One of our academic authors is biomathematician Shelly Deforte, who recently took up a post-doctoral position in bioinformatics at the University of Montreal. She describes her position as fully involved in supporting the research projects of a biochemistry lab by “writing custom code to do custom analysis” on the data.

Shelly’s work focuses on artificial intelligence, machine learning and in silico modelling, writing code that runs algorithms to analyze the libraries of data generated by experimental workflows. Her field of interest is intrinsically disordered proteins, looking for evidence of a lack of stable structure among proteome structure and sequence databases. Since structure heavily influences function, intrinsic disorder could signal a highly versatile protein; making predictive sense of how these molecules might behave or bind with other factors is important in drug discovery, for example.

Talk Science provided editing for two of Shelly’s primary research papers, a service she describes as extremely valuable. This included editing, copy-editing, proofreading and some fact-checking, ultimately delivering a final manuscript that was ready for journal submission.

So how does this kind of support help an academic biomathematician?

In the academic world, researchers are under constant pressure to publish their findings, submitting them to peer-reviewed journals, conferences and other venues. Publication enhances reputation for the academic institution as well as the scientist. Often the data come from collaborative research projects, meaning that writing a primary paper involves many authors in the draft and revision processes. Eventually, with all the changes and additions, it becomes difficult to spot grammatical errors, inconsistencies and typos.

“After all the revision and editing you and your authors do, it’s impossible not to become blind to the paper,” Shelly explained. “Also, when you’re familiar with a subject, it’s not always easy to see when something lacks clarity for the reader.”

Hiring an external editor can also help get a paper published. Since reviewers seem to prefer highly polished papers, submitting a manuscript that requires very little work prior to publishing increases the odds of acceptance. Furthermore, as journals economize, providing less editorial support and prepress oversight for submissions, errors can make it all the way into print. Shelly suggests that it is a good idea to avoid submitting them in the first place: working with a Talk Science editor to oversee final document revisions will prevent the risk of their immortalization!

Bioinformatics is rapidly becoming more important to scientific research as researchers struggle to make sense of complex data outputs. Biological systems under investigation are much more complicated than computers can deal with without specific programs to handle the multidimensional information downloads for analysis. Biomathematicians like Shelly are becoming increasingly involved in experimental design to ensure that data submission is in the correct format. When handled correctly, computational support in the form of algorithms, artificial intelligence and machine learning save time, sparing scientists from traditional manual analysis to speed up results.

In providing manuscript editing and submission services, Talk Science hopes to help share Shelly’s science effectively as well as free up valuable research time to pursue new directions in protein bioinformatics.

Learn more about our Talk Science clients in our client showcases.

Learn more about intrinsically disordered proteins in this useful review:
DeForte, S., & Uversky, V.N. (2016). “Order, disorder, and everything in between,” Molecules, 21(8), 1090, doi: 10.3390/molecules21081090.

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