Wednesday, September 30, 2015
As mass spectrometry–based proteomics advances, so does the availability of data on post-translational modifications (PTMs). Edwards et al. (2014) recently modified the existing ReportSites analysis tool1 to expand the range of interpretations, allowing researchers to interrogate data for structural relationships between PTMs in both 2-D and 3-D.2 Within the cell, protein synthesis and activity are controlled Read the rest of this article
The post ReportSites: Spatial Awareness for Post-Translational Modifications appeared first on Accelerating Science.
from Accelerating Science » Amanda Maxwell http://ift.tt/1iKRN08
Tuesday, September 29, 2015
For consumers and food safety professionals alike, noroviruses (family: Caliciviridae) are a serious issue. Although there are multiple routes for infection, foodborne disease is a major cause of outbreaks worldwide. According to a recent paper from the Centers for Disease Control (CDC) authored by Verhoef et al. (2015), almost 1 in 7 cases of norovirus disease Read the rest of this article
The post Foodborne Norovirus – Genotyping to Track the Virus appeared first on Accelerating Science.
from Accelerating Science » Amanda Maxwell http://ift.tt/1MWT5SP
Monday, September 28, 2015
Sunday, September 27, 2015
Wednesday, September 23, 2015
Gorshkov et al. (2015) describe SuperQuant as a quantitative proteomics data processing tool that “uses complementary fragment ions to identify multiple co-isolated peptides during tandem mass spectrometric analysis.”1 The tool is implemented as a processing node on Thermo Scientific’s Proteome Discover software (revision 2.x), and the researchers demonstrate its inherent advantages through deep proteome characterization using the Read the rest of this article
The post Dealing with Multiples: SuperQuant Processing and Co-Isolated Peptide Identification appeared first on Accelerating Science.
from Accelerating Science » Amanda Maxwell http://ift.tt/1FeRkO9
Tuesday, September 22, 2015
Monday, September 21, 2015
With rapid progress in mass spectrometry–based proteomics technology, biomarker discovery through characterization and quantitation of post-translational modifications (PTMs) is becoming more routine for researchers. In a useful review of methodologies, Pagel et al. (2015) give an overview of what is currently available to researchers and take a look at what may be in place in Read the rest of this article
The post Proteomics for Clinical Relevance: PTMs and Biomarker Discovery appeared first on Accelerating Science.
from Accelerating Science » Amanda Maxwell http://ift.tt/1NGEmtP
Thursday, September 17, 2015
Biobank data management needs are becoming more complex as biosample collections grow to meet research demands. In the field of personalized medicine, for example, researchers require access to increasing numbers of samples to characterize the individual traits and population dynamics that could improve treatment options. As a solution for this growing problem, Dowst et al. Read the rest of this article
The post Acquire: A Tailor-Made Solution for Biobanking Data Management appeared first on Accelerating Science.
from Accelerating Science » Amanda Maxwell http://ift.tt/1KisGuX
Tuesday, September 15, 2015
Bioresources, described as systematically cataloged collections of biological data kept either with or without the relevant biosamples, are valuable assets for the research community. However, this value is not reflected in the way that bioresources are cited in primary research papers. Since citation is not standardized, indexing tools for publications cannot accurately search and retrieve Read the rest of this article
The post Standardizing Bioresource Citations for Added Value appeared first on Accelerating Science.
from Accelerating Science » Amanda Maxwell http://ift.tt/1KjTrfq
Friday, September 11, 2015
Thursday, September 10, 2015
There is no point in collecting precious specimens only to find that they have deteriorated while in biobanking cryostorage. However, it is not just storage that can depreciate sample quality: shipping can also affect final quality. Posevitz-Fejfár et al. (2014) looked at the effect of transportation, focusing on biobanking peripheral blood mononuclear cells (PBMCs) from Read the rest of this article
The post Biobanking Viable Immune Cells—Transportation Matters! appeared first on Accelerating Science.
from Accelerating Science » Amanda Maxwell http://ift.tt/1i0fIbv
Wednesday, September 09, 2015
In an elegantly presented review, Fouhy and coauthors (2015) discuss the case for combining proteomics into the metagenomics workflow currently in operation for examining factors of microbial resistance that threaten to scupper modern medicine.1 Antibiotic resistance has been around since…well, since before the advent of antibiotic use in medicine. However, the recent development of microbial resistance Read the rest of this article
The post Proteomics: The Final Frontier in Metagenomic Investigation of Antibiotic Resistance? appeared first on Accelerating Science.
from Accelerating Science » Amanda Maxwell http://ift.tt/1IY4bPE
Tuesday, September 08, 2015
from The V3H.com - Port Moody, Coquitlam, Port Coquitlam » » Amanda Maxwell http://ift.tt/1Ng2ZNL
Using tandem solid phase extraction (SPE) in conjunction with gas chromatography tandem mass spectrometry (GC-MS/MS), Xu et al (2015) present a sensitive assay for identifying and quantifying dangerous polycyclic aromatic hydrocarbons (PAHs) in edible oils1. Since the discovery of their toxic attributes, PAHs have been under close scrutiny by regulatory authorities worldwide. They are a Read the rest of this article
The post Edible Oil Safety Monitoring by Tandem SPE and Mass Spectrometry appeared first on Accelerating Science.
from Accelerating Science » Amanda Maxwell http://ift.tt/1XF3dmr
Monday, September 07, 2015
Sunday, September 06, 2015
|clockwise from the left: hammered silver copper wire necklaces (blackstone and carnelian) | sterling silver knot ring and copper scrap ring | argentium silver wave ring | sterling silver twisted ring (all currently available at the Blackberry Gift Shop in Port Moody Arts Centre|
It is difficult, but I find that when I make some art, I feel more fulfilled.
How do I go forward and fit it back into my life?
Reminder to self: creativity 365
Thursday, September 03, 2015
Translating science into practice has benefits for food producers seeking to improve food safety for consumers. Applying a tool like predictive microbiology to a commercial environment could help producers plan work processes effectively with consumer safety in mind. Output from predictive models could predict shelf life and identify control points, for example. However, implementation of Read the rest of this article
from Accelerating Science » Amanda Maxwell http://ift.tt/1JAm5tn
Wednesday, September 02, 2015
Examining the complex cellular metabolic pathways in neurons from patients with Alzheimer’s disease (AD) has uncovered potential areas for therapeutic discovery. Moore et al. (2015) recently demonstrated that the metabolism of amyloid precursor protein (APP), a protein giving rise to the Aβ peptide fragments in amyloid plaque that are hallmarks of the disease, affects another AD Read the rest of this article
The post Proteomic Analysis of Neuronal Pathways Implicated in Alzheimer’s Disease appeared first on Accelerating Science.
from Accelerating Science » Amanda Maxwell http://ift.tt/1EydHxC